Houston used most of its 2011 draft picks on defensive players, and Ryans had a reduced role because of more injuries and the emergence of Brian Cushing and rookie Brooks Reed.
The Texans ranked second in total defense last season (285.7 yards per game), finished 10-6 and earned their first division title and playoff berth.
After a three and out from the Colts' offense, Manning and the Broncos again take advantage and drive 83-yard to score on another Thomas touchdown reception.
He was also durable, starting all 16 games in his first four seasons.
He tore his left Achilles tendon in the sixth game of 2010 and the season collapsed, with the Texans dropping eight of their final 10 games.
The Eagles now have the 89th pick overall, while the Texans have the 77th pick.
The 27-year-old linebacker and team captain leaves Houston as the Texans’ all-time leader with 637 tackles while also contributing eight sacks, six forced fumbles, eight fumble recoveries and two interceptions in his six-year career.